<?xml version="1.0" encoding="UTF-8"?>

<wo-patent-document lang="en" status="Examined" country="MY">
  <wo-bibliographic-data status="Under Substantive Examination">
    <application-reference>
      <document-id>
        <country>MY</country>
        <doc-number>PI2025006022</doc-number>
        <date>20250930</date>
      </document-id>
    </application-reference>
    <priority-claims>
      <priority-claim sequence="0001" kind="national">
        <country>US</country>
        <doc-number>62/560,365</doc-number>
        <date>20170919</date>
      </priority-claim>
    </priority-claims>
    <parties>
      <applicants>
        <applicant sequence="0001" app-type="applicant" designation="all">
          <addressbook lang="en">
            <name>REGENERON PHARMACEUTICALS INC.</name>
            <address>
              <address-1>777 Old Saw Mill River Road, Tarrytown, NY 10591</address-1>
              <country>US</country>
            </address>
          </addressbook>
          <nationality>
            <country/>
          </nationality>
          <residence>
            <country>US</country>
          </residence>
        </applicant>
      </applicants>
      <inventors>
        <inventor sequence="0001">
          <addressbook lang="en">
            <name>TANG, Xiaolin</name>
            <address>
              <address-1>c/o Regeneron Pharmaceuticals Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591</address-1>
              <country>US</country>
            </address>
          </addressbook>
        </inventor>
        <inventor sequence="0002">
          <addressbook lang="en">
            <name>WASINGER, Stacy</name>
            <address>
              <address-1>c/o Regeneron Pharmaceuticals Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591</address-1>
              <country>US</country>
            </address>
          </addressbook>
        </inventor>
        <inventor sequence="0003">
          <addressbook lang="en">
            <name>SPRITZER, Danya</name>
            <address>
              <address-1>c/o Regeneron Pharmaceuticals Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591</address-1>
              <country>US</country>
            </address>
          </addressbook>
        </inventor>
        <inventor sequence="0004">
          <addressbook lang="en">
            <name>PATEL, Mayank</name>
            <address>
              <address-1>c/o Regeneron Pharmaceuticals Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591</address-1>
              <country>US</country>
            </address>
          </addressbook>
        </inventor>
      </inventors>
      <agents>
        <agent sequence="0001" rep-type="agent">
          <addressbook lang="en">
            <name>TIMOTHY SIAW YEAN HWA</name>
            <address>
              <address-1>C/O SHEARN DELAMORE &amp; CO., 7TH FLOOR, WISMA HAMZAH-KWONG HING, NO. 1, LEBOH AMPANG 50100 KUALA LUMPUR</address-1>
              <country>MY</country>
            </address>
          </addressbook>
        </agent>
      </agents>
    </parties>
    <invention-title lang="en">METHODS OF REDUCING PARTICLE FORMATION AND COMPOSITIONS FORMED THEREBY</invention-title>
    <wo-national-office-event national-office-event-type="OPI" event-name="Open for public inspection">
      <wo-national-office-event-date>
        <date>20190319</date>
      </wo-national-office-event-date>
    </wo-national-office-event>
    <wo-national-office-event national-office-event-type="Filed" doc-number="PI2025006022" event-name="Filing">
      <wo-national-office-event-date>
        <date>20250930</date>
      </wo-national-office-event-date>
    </wo-national-office-event>
    <wo-national-office-filing-data appl-type="National Patent" file-type="">
      <kind-of-protection></kind-of-protection>
    </wo-national-office-filing-data>
  </wo-bibliographic-data>
  <abstract lang="en">
    <p num="0001">Biopharmaceutical compositions and drug products disclosed herein exhibit reduced amounts of subvisible particle formation. Compositions and drug products disclosed herein comprise a protein and a surfactant or stabilizer including high percentage amounts (e.g., at least 97%) of a long-chain fatty acid ester. Also disclosed herein are methods of preparing and storing such compositions and drug products. Figure 1</p>
  </abstract>
</wo-patent-document>
